The Autumn issue features the challenges and opportunities of Brexit and the RSE’s visit to China. It also announces the £52k legacy gratefully received by the late Professor Patrick Meares to support the RSE’s Grants Programme for Fellows and Young Academy of Scotland members. Also, the RSE are pleased to receive a special portrait of RSE ‘grandfather’ Colin Maclaurin, a leading Scottish mathematician with close connections to the RSE. In addition, within this issue, there are details of the Young Academy of Scotland’s Brexit Report on the impact of Scotland. Forward looking, the issue announces the forthcoming 2018 Pharmacology Conference Dinner which celebrates 250 years of pharmacology in Edinburgh at the National Museum of Scotland.